What tests are done for recurrent pregnancy loss?
I have had three miscarriages before 10 weeks, one after IUI and two natural. Which tests are evidence-based?
Short answer: Guideline-based workups often include parental karyotypes, antiphospholipid antibody panel, uterine cavity evaluation and thyroid assessment. Many popular immune panels lack strong evidence; avoid large unproven packages.
Answer #1
Core evaluations
Document each loss carefully. Test for antiphospholipid syndrome with the correct antibody panel on two occasions when indicated. Image the cavity for septum or adhesions. Karyotype both partners. Review sperm DNA fragmentation selectively. Control thyroid and diabetes.
Dr. Ananya Krishnan, MD Reproductive Medicine. Answered 2026-05-11
Answer #2
Be cautious with experimental immune protocols
Broad natural-killer-cell panels, empiric IVIG, or multiple unexplained anticoagulants are not routine first-line care for all RPL patients. Ask what diagnosis a test will change. Supportive care plus treating documented abnormalities remains the foundation; IVF with PGT-A is a tool for selected couples, not mandatory for everyone.
Dr. Fatima Khan, MD Reproductive Medicine. Answered 2026-05-11
Call your clinic or go to the hospital the same day if you have
- Heavy bleeding
- Signs of infection after miscarriage management
- Severe depression needing urgent support
Want help finding a clinic?
Get matched to one ART-registered clinic after consent — not a directory of calls.
Answers are general education for patients in India, not a diagnosis or personal medical advice. Best IVF Centers is a fertility matching service, not a clinic or hospital. Always follow your treating doctor's instructions. In an emergency, go to the nearest hospital.